Leptin: its pharmacokinetics and tissue distribution
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles
BACKGROUND This study explored the pharmacokinetics, tissue distribution, and excretion profile of zinc oxide (ZnO) nanoparticles with respect to their particle size in rats. METHODS Two ZnO nanoparticles of different size (20 nm and 70 nm) were orally administered to male and female rats, respectively. The area under the plasma concentration-time curve, tissue distribution, excretion, and th...
متن کاملPharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat
Icariin is one of the predominant flavonoids contained in Herba Epimedii (Yin-yang-huo in Chinese), a well-known Chinese medicine for the treatment of cancers and immune system diseases. Although Herba Epimedii has been widely used in China and there are so many and various research reports on the herbal drug and its main flavones, very limited data is available on the tissue distribution and b...
متن کاملPharmacokinetics and tissue distribution of anidulafungin in rats.
This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.
متن کاملPharmacokinetics, tissue distribution, and excretion of salidroside in rats.
The present study investigated the pharmacokinetics, excretion, and tissue distribution of salidroside, a main active constituent in the roots of Rhodiola species. The plasma concentration declined rapidly following the intravenous dosing at 7.5, 15, and 30 mg/kg with a short half-life time of about 1 h. The mean values of area under the concentration-time curve (300.48 ± 36.73, 514.51 ± 134.99...
متن کاملPharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats.
The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide, a cyclooxygenase-2 inhibitor, were investigated in rats. Celecoxib was metabolized extensively after i.v. administration of [(14)C]celecoxib, and elimination of unchanged compound was minor (less than 2%) in male and female rats. The o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 1998
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0800656